Endocrine Abstracts

A 50-year-old man admitted to our institution with labile hypertension. His blood pressure was 150/90 mmHg and the pulse rate was 96 beats per minute. He had hypertensive attacks every 2–3 days. His blood pressure was found 210/110 mmHg at hypertensive attact. He had palpable thyroid nodule. Ultrasonography of the thyroid gland showed a 2.6 cm sized, irregularly marginated, calcified thyroid nodule. His serum free thyroxine (fT4), free triiodothyronine (fT3), thyrotropin ...

Many causes of levothyroxine malabsorption have been described in the literature such as celiac disease, giardiasis, severe liver cirrhosis and drug interactions. A 27-year-old woman admitted to our institution with overt hypothyroidism symptoms. She had total thyroidectomy for thyroid papiller carcinoma and was using 400 μg/day levothyroxine (LT4). Her serum free thyroxine (fT4), free triiodothyronine (fT3) and thyrotropin stimulating hor...

Introduction: The non-insulinoma pancreatogenous hypoglycemia syndrome (NIPHS) identifies a group of hyperinsulinemic hypoglycemic patients with unique clinical, diagnostic, surgical, and pathologic features. A selective arterial calcium stimulation test (SACST) with hepatic venous sampling can be performed to distinguish between a focal abnormality (insulinoma) and a diffuse process (islet-cell hypertrophy/nesidioblastosis). In patients with insulinoma, the response is positi...

Bone mineral disorders usually resolve after successful kidney transplantation. Serum calcium (Ca), phosphorus (P) and parathyroid hormone (PTH) levels tend to normalize within time. Serum Ca levels >10.2 mg/dL and PTH levels >150 pg/mL at 6th−12th months of transplantation is defined as persistent hypercalcemia and persistent hyperparathyroidism (PHPT) in recipients with normal graft function. Reported persistent hypercalcemia prevalence varies in wide range bet...

Aims: Glomerular and tubulointerstitial damage plays a role in renal function failure in diabetic patients. While both serum and urine levels of neutrophil gelatinase-associated lipocalin (NGAL) show significantly increased levels in acute renal pathologies, the NGAL increase in active phase indicates a reversible condition in chronic cases. In this study, we determined if urinary excretion of NGAL can be used as an early indicator of diabetic nephropathy, which causes chronic...

Background: It is known that obesity-related renal damage,regardless of type 2 diabetes and hypertension, may improve by weight-loss modalities. In this study, we aimed to evaluate the effect of bariatric surgery on glycemic and lipid parameters, anthropometric measurements, renal parameters and urine NGAL (Neutrophil Gelatinase-Associated Lipocalin) levels in obese diabetic or nondiabetic patients who has not respond to medical treatmentMaterials and me...

Weight gain and obesity are frequent problems after kidney transplantation. Potential causes of weight gain are use of immunosuppressive drugs and changes in life style such as dietary intake and insufficient physical activity. This study aimed to evaluate the different general and abdominal obesity criterias and post-transplant weight changes in kidney transplant recipients.Methods: This prospective study included consecutive 112 (62 females, 50 males) ...

Background: Isotretinoin has been used for many years to treat moderate or severe nodulocystic acne, disorders of sebaceous gland and keratinization and in the prevention of skin cancer. Certain types of retinoids may cause abnormalities in serum thyroid function tests by suppressing thyroid stimulating hormone (TSH). However, it is uncertain whether systemic isotretinoin has any effect on thyroid functions.Case: 18 years old woman has admitted to our ho...

Introduction: The most frequently secreted hormone in pituitary adenomas is prolactin, but prolactin and growth hormone co-secretion are also seen at not an uncommon frequency. Co-secretion of growth hormone has also been reported after long-term follow up in the prolactinoma patients which well controlled with cabergoline therapy. In this case report, we aimed to discuss the results of cabergoline therapy in a case of co-secreting GH and prolactine with a normal IGF1 level an...

Case: An 18-years-old female patient suffering from headache, pituitary magnetic resonance imaging (MRI) revealed a lesion compatible with pituitary microadenoma; 8.5×5 mm in size, in the right lateral and extending to the midline of the pituitary gland. Cabergoline treatment was initiated in the external center with a prolactin level of 77 ng/ml and no other pituitary hormone abnormality. Unplanned pregnancy occurred in the patient who continued this treatment for about ...